Alterations in the antioxidant profile in patients with colorectal carcinoma

The present study was carried out in the patients diagnosed with the colorectal cancer and is about to get the treatment. Age and gender matched controls were also included in the study. The blood samples were collected and the biochemical parameters like Total antioxidant activity, lipid peroxidation, Glutathione, Vitamin E, Vitamin C and catalase were estimated. The significant decreased levels of total antioxidant activity, increased lipid peroxidation levels, decreased levels of glutathione, catalase, vitamin E and vitamin C were observed in the colorectal cancer subjects when compared with the control subjects. It is evident from the present study that oxidative stress plays an important role in the advancement of colorectal cancer and might be an additional parameter in the pathology of cancer progression.