Hepatoprotective effect of leaves of Balanites roxburghii against carbon tetrachloride-induced hepatic damage in rats

The methanolic extract of leaves of Balanites roxburghii (BLR) was evaluated for its hepatoprotective activity against carbon tetrachloride (CCl₄)-induced hepatic damage in rats. It was evaluated by measuring levels of serum marker enzymes like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and total bilirubin (TBR). The histological studies were also carried out to support the above parameters. Administration of BLR (200 and 400 mg/kg, p.o.) markedly prevented CCl₄-induced elevation of levels of serum GPT, GOT, ALP and TBR. A comparative histopathological study of liver exhibited near to normal architecture, as compared to CCl₄-treated group.