aIndian Immunologicals Limited, Rakshapuram, Gachibowli, Hyderabad, India.
bDepartment of Veterinary Parasitology, Bombay Veterinary College, Mumbai, India.
cSchool of Biotechnology, Jawaharlal Nehru Technological University, Hyderabad, India.
dDepartment of Biochemistry, Indian Institute of Sciences, Bangalore, India.
*For Correspondence - srini@indimmune.com
Use of recombinant Bm95 isolated from an Argentinean strain of Rhiphicephalus microplus A as a vaccine candidate to control the tick infestation in India was investigated. Recombinant Bm95 expressed in yeast, Pichia pastoris. Purified protein blended into a vaccine using aluminium hydroxide as an adjuvant. An adverse effect on the reproduction of ticks was observed in vaccinated animals indicating reduced the environmental contamination and source of infestation indicating its use of Bm95 in the immunological control of ticks in India.
Tick, Bm95, Rhiphicephalus, tickborne diseases
