Formulation and Evaluation of Transdermal Patches of Ondansetron Hydrochloride Using Various Polymers in Different Ratios

This paper describes the formulation and evaluation of transdermal patches of Ondansetron Hydrochloride. The films were formulated using different hydrophilic and lipophilic polymers combination of hydrophilic-lipophlic polymers, ethyl cellulose: poly vinyl pyrrolidine. The polymeric films of Ondansetron Hydrochloride were prepared using film casting technique on mercury substrate. The study is also extended to investigate the effect of plasticizer such as dibutyl phthalate and propylene glycol and effect of penetration enhancer oleic acid by using kesharychein diffusion cell. The films were evaluated for physico-chemical properties. In vitro drug diffusion study through rat skin indicates hydrophilic polymer showed higher release than the liphophilic and hydrophilic-lipophilic combination. The release rate was found to follow first order kinetics. Also permeation enhancer was found to give favourable permeation enhancement.