Tool development for Prediction of pIC₅₀ values from the IC₅₀ values - A pIC₅₀ value calculator

Half maximal inhibitory concentration (IC₅₀) value measures the effectiveness of compound inhibition towards biological or biochemical utility. Quantitative measure indicates the quantity required for particular inhibitor to inhibit a given biological process (i.e. an enzyme, cell, cell receptor or microorganism) by half. Occasionally, it is also converted to the pIC₅₀ scale (−log IC₅₀), in which higher values indicate exponentially greater potency. These are the experimental values which are predicted and coded in Nanomolar (nM-10⁻⁹) and micromolar (μM10⁻⁶). These IC₅₀ values differs in wide range of molecules. So, there are Varity of ranges of applications in molecular modeling techniques especially 3D-QSAR, CoMFA, CoMSIA, Pharmacophore Mapping and many more applications. So, to predict the narrow value from the experimental value, the successful formula is described here to calculate the pIC₅₀ value. As of now, no tool available as open source software to provide the value of pIC₅₀ from IC values as pICcalculator In this work 5050. we developed the tool for the prediction of pIC₅₀ values from the IC₅₀ in nanomolar and micromolar using the JavaScript programming language, which is available at the Sanjeevslab webpage: http://www.skysanjeev.110mb.com/index.php?p=1_7_Tools