Genome Analysis of Selected Foodborne Pathogens for Identification of Drug Targets

As the bacterial pathogens are showing growing resistance against existing antibiotics, there is an urgent requirement of pharmaceutical companies for designing new and effective drugs against these pathogens causing common foodborne diseases. We have performed in-silico genomic analysis of two virulent foodborne pathogens Listeria monocytogenes and Bacillus cereus for identification of potential drug targets for novel drug discovery. Our prediction found small number of genes of each pathogen to be targeted for drug designing. The gene products are found to be involved in various important regulatory proteins, membrane proteins and hypothetical proteins of unknown function of bacterial species. Further using KEGG pathway prediction various enzyme proteins were found which have active role in biosynthetic and metabolic pathways. The primary goal of this study was to provide a valuable resource of drug targets to the scientific community. The current data is included in “Drug Targets Protein Database” developed by our group.