Defence Science Journal
  • Year: 2008
  • Volume: 58
  • Issue: 3

Preparation of oxime HI-6 (Dichloride and Dimethanesulphonate)-antidote against nerve agents

  • Author:
  • Kamil Kuca1,2, Petr Stodulka1,3, Martina Hrabinova1, Petra Hanusova3, Daniel Jim1,2, Bohumil Dolezal3
  • Total Page Count: 6
  • Page Number: 399 to 404

1Center of Advanced Studies, Hradec Kralove, Czech Republic.

2Department of Toxicology, Hradec Kralove, Czech Republic.

3Vakos XT, Prague, Czech Republic.

Abstract

Because of the threat of misuse of nerve agents as terroristic weapons by the terrorists, an immediate need is felt for the preparation of antidotes on large-scale basis. HI-6 (dichloride and dimethanesulphonate) salt are the most promising acetylcholinesterase reactivators used as causal antidotes in nerve agents intoxication. In this study, rapid and large-scale preparation of oxime HI-6, the most promising reactivator has been described.

Keywords

HI-6, acetylcholinesterase, nerve agent, quaternary salts, oxime, reactivator, antidote, organophosphate