Response of Fresh Garlic Extract on Plasma Membrane H+ATPase of Candida glabrata

Candida glabrata is among the most common opportunistic fungal pathogens in humans. Oral Candida infection has been reported to be on increase with pulmonary tuberculosis patients. Antifungal drugs like fluconazole and ketoconazole are now not proving very effective against C.glabrata. C.glabrata is inherently more resistance to fluconazole than C.albicans but it is still highly vulnerable to polyene drugs such as amphotericin B and nystatin. Fresh Garlic Extract (FGE) has been reported to have antifungal properties due to presence of organo-sulphur compounds. Thus it is having the scope in evolving good antifungal drug. These studies were designed to investigate the effect of FGE on the basis of proton extrusion activity of C.glabrata. Results on the activity of FGE against pathogenicity and growth of C.glabrata have provided positive indication.