Inhibition Activity of Alpha Amylase and Antioxidant Activity of Breadnut (Artocarpus camansi) Leaf Extract from Different Leaf Position

Diabetes mellitus is a disorder which is linked to alpha amylase function in hydrolyzing complex carbohydrates into monosaccharides. Plants bioactive component that act as an alpha amylase inhibitor has a potency to answer the problem. This research is a descriptive research to observe alpha amylase inhibition activity and antioxidant activity of Breadnut (Artocarpus camansi) leaf extract (BLE) from different leaf position. Breadnut leaf from different position were extracted with water, concentrated by rotary vacuum evaporator and freeze dried to obtain dried extract. A potential to inhibit carbohydrates hydrolysis was shown by Breadnut leaf dried extract with alpha amylase activity of inhibition (IC₅₀) of young leaf, mature leaf and old leaf, respectively, 1888.83 μg/ml, 2353.84 μg/ml, and 3199.35 μg/ml; antioxidant activity (IC₅₀) of 748.02 μg/ml, 1266.17 μg/ml, 1377.00 μg/ml and moisture content of Breadnut leaf dried extract of 10.17%, 10.13% and 10.15%. Breadnut leaf dried extract has potential to inhibit activity of alpha amylase and antioxidant activity.