Immunoglobulin are not produced in normal liver, but in chronic hepatic disease, they have been identified in the lymphoid and plasma cells infiltrating portal areas and parenchyma. It is reported that IgG appears to be the predominant Ig synthesized by mesenchymal cell in active chronic hepatitis and the IgM is the predominant Ig synthesized by lymphoid aggregates around the damaged bile ductules in primary bilary cirrhosis. In present study significant rise in the levels of IgA and IgM are observed in viral hepatitis patients.
