*Department of Physiology, Shri. M. P. Shah Medical College, Jamnagar (Gujarat), India.
**Department of Physiology, AIIMS, Rishikesh, India
Online published on 13 February, 2013.
Hyperglycemia and hypertension are known to be risk factors for the development of proteinuria in patients with diabetes, which leads to progression of end stage renal disease.
To study the effect of various factors on progression of diabetic nephropathy in type 2 diabetic patients.
We investigated factors affecting progression of nephropathy by measuring serum creatinine (s-Cr), glomerular filtration rate (GFR) level in 70 (45 men and 25 women) type 2 diabetes mellitus patients on antihypertensive treatment.
The survey was done for 6 months during which 40 (Group 1) - uncontrolled type 2 diabetes mellitus having S. Creatinine <1.2 mg/dl compared with 30 (Group 2) -uncontrolled type 2 diabetes mellitus having S. Creatinine ≥1.2 mg/dl. Mean S. Creatinine 2.1mg/dl, mean SBP 141.37mmHg, mean duration of diabetes mellitus 9.26years, mean HbA1c 9.0%, mean Serum cholesterol 215.63 mg/dl and mean GFR 36.75 ml/min was seen in group 2 patients. In group 2 mean SBP, Duration of DM, HbA1c and serum creatinine were significantly higher and GFR significantly lower than group1 (P < 0.05).
hyperglycemia (HbA1c), duration of DM and hypertension are the risk factors that lead to progression of diabetic nephropathy with decline in GFR.
Type2 diabetes mellitus (DM), Diabetic nephropathy (DN), serum creatinine, GFR, hypertension
