1Assistant Professor, Department of Medicine, B.J. Medical College, Ahemedabad, 380016
2Head of Unit Department of Medicine, B.J. Medical College, Ahemedabad, 380016
*Author for correspondence: Dr. Cecil Parmar, Department of Medicine, B. J. Medical College, Ahemedabad. – 380016. E-mail: dr.cecil114@gmail.com
Online published on 22 May, 2014.
The sub acute demyelinating polyneuropathy knows as Gullian –Barre syndrome improves more rapidly with plasma exchange. We conducted study of 50 patients to compare response of plasma exchange vs IVIG.
We have enrolled patients who had been diagnosed as gullian –barre dyndrome, which include clinical laboratory and electrophysiological diagnostic features. They were randomly assigned to receive either five plasma exchanges (50 ml/kg) on five separate sitting over 1–2 weeks or five doses of IVIg (0.4g/kg per day).The predefined outcome measure was improvement at four weeks by at least one grade of motor function.
Median time to start recovery after plasma exchange was 6 days compare to 5 days of IVIG. 70% of patients improve more than one grade at 4 weeks compare to 69.23% of IVIG.
In the acute Gullian-Barre syndrome, treatment with IVIg is at least as effective as plasma exchange.
Gullian barre syndrom, Plasma exchange, IVIG
