1Deptt. of Physiology, Mahatma Gandhi Medical College, Jaipur (Raj.)
2Deptt. of Biochemistry, S.M.S. Medical College, Jaipur (Raj.)
*Author for Correspondence: Dr. Mamta Mahla, Assistant Professor, Department of Physiology, Mahatma Gandhi Medical College, Sitapura, Jaipur (Raj.), Mobile: +91 94149 64440, E-mail: mamtamahla@gmail.com
Online published on 22 May, 2014.
Menopause is a natural step in the process of ageing and free oxygen radicals have been proposed as important causative agents of ageing. The antioxidant system seems to be affected in post-menopausal women due to deficiency of estrogen, which is a powerful antioxidant. In view of this background, present study was carried out to find correlation between menopause and antioxidant status, if any.
Status of antioxidants was determined by spectrophotometric estimation of Superoxide Dismutase (SOD), and Ascorbic Acid in blood/serum of 105 women. The subjects consisted of 35 women of three distinct groups, namely, reproductive age, perimenopausal, and post-menopausal. Data obtained was analyzed by student's t- test, ANOVA, and Pearson's correlation coefficient (r). P < 0.05 was considered significant.
Peri- and post-menopausal women exhibited significantly low erythrocyte SOD and serum ascorbic acid, as compared to the women of reproductive age.
Findings of this study corroborate the hypothesis that gradual loss of ovarian function is associated with a concomitant decrease in antioxidant status.”
ANTIOXIDANTS, ASCORBIC ACID, MENOPAUSE, OXIDATIVE STRESS, SUPEROXIDE DISMUTASE
