1Associate Professor in Cardiac Anesthesia, U N Mehta Institute of Cardiology & Research Centre, B. J. Medical College, Ahmedabad-16
2Assistant Professor in Cardiac Anesthesia, U N Mehta Institute of Cardiology & Research Centre, B. J. Medical College, Ahmedabad-16
3Associate Professor in Cardio Vascular Thoracic Surgery, U N Mehta Institute of Cardiology & Research Centre, B. J. Medical College, Ahmedabad-16
Midazolam and ketamine are useful premedication orally to decrease anxiety in children. We compared the effects of high dose midazolam with ketamine and with low dose combination of midazolam and ketamine both.
75 children between 6 months to 10 years with congenital heart disease were posted for surgeries were randomly selected for 3 groups. Group A received midazolam 0.75mg/kg p.o., Group B received ketamine 8mg/kg p.o., and Group C received midazolam 0.5mg/kg and ketamine 4mg/kg p.o. Heart rate, blood pressure, respiratory rate, oxygen saturation, anxiety score and sedation score were noted at 10, 20, 30 minutes after premedication and at time of parental separation and face mask application. Standard general anaesthesia technique was employed.
There were linear decreasing trends in sedation score and anxiety score were noted compare to presedation score. However, group C shows superior effect at the time of parental separation and face mask application. Hemodynamic changes were similar in all groups.
Combination of oral midazolam and ketamine at low dosage is excellent premedication for sedation and anxiolysis at the time of parental separation and face mask application and are highly acceptable to children and their parents with minimum side effects.
Premedication, Pediatric patients, Oral midazolam, Oral ketamine
