Comparison of lipid profile in diabetic and non diabetic male and female below and above the 45 years of age group

Incidence of diabetes mellitus in human population has reached epidemic proportions worldwide, and it is increasing at rapid rate. Many large scale analyses have demonstrated a nearly linear correlation between the total cholesterol and low density lipoprotein (LDL) cholesterol and the severity of atherosclerosis. It has also been seen the inverse relationship between symptomatic atherosclerosis and the high density lipoprotein (HDL) cholesterol level.

The goal of our study is to estimate blood sugar, total cholesterol, HDL and LDL level in male and female.

40 male and 40 female are below the 45 years of age and 40 male and 40 female are above the 45 years of age. In the present study 80 normal individuals (Controls) and 80 diabetic patients suffering from Non-insulin dependent diabetics mellitus have been investigated. The entire subject were instructed about study and written consent taken. History and clinical examination was done. Blood sugar, total serum cholesterol, serum LDL cholesterol and serum HDL cholesterol level is estimated in biochemistry laboratory by calorimetric method. Statistical analysis was done by unpaired t test. P value less than 0.05 considered as a significant.

Total cholesterol level is not significantly (p > 0.05) change in diabetic and non diabetic. HDL cholesterol level is significantly (p < 0.001) lower in diabetic patients as compared to non diabetics. LDL cholesterol is not significantly (p > 0.05) change in diabetic and non diabetic. Total cholesterol level and LDL cholesterol level are significantly (p < 0.001) higher in above 45 years male and female than below 45 years of male and female. HDL cholesterol level is significantly (p < 0.001) higher in above 45 years of female than below 45 years of female but HDL cholesterol level is not significantly (p > 0.05) change in below and above 45 years of male.

Total cholesterol level is not significantly (p > 0.05) change in diabetic and non diabetic. HDL cholesterol level is significantly (p < 0.001) lower in diabetic patients as compared to non diabetics. LDL

cholesterol is not significantly (p > 0.05) change in diabetic and non diabetic.