Department of Anaesthesisa, V.S. Hospital, Ellisbridge, Ahmedabad, pin 38000
Online published on 21 September, 2015.
The laryngotracheal stimulation is known to cause reflex sympatho adrenal response with marked increase in heart rate and blood pressure. Arrhythmias can be precipitated. The harmful nature of this response has been noted in patients at risk. Various techniques and drugs have been advocated to decrease the hemodynamic response and none of them is totally acceptable. Hence there is a need to find a simple and effective method.
The present clinical comparative study was done in 50 normotensive, ASA Grade I and II patients scheduled for various elective surgical procedures under general anesthesia with endotracheal intubation. The objectives of the study were to observe the variations of sympathetic response to laryngoscopy and intubation in study groups and to study the effectiveness of Clonidine hydrochloride and Esmolol hydrochloride in attenuating this sympathetic response. All the cases were divided randomly into two groups with 25 patients in each group. Group-I was Clonidine group and Group-II was Esmolol group.
Among the two drugs Esmolol hydrochloride showed better attenuation of sympathetic response than Clonidine hydrochloride which is statistically highly significant.
