Impact of aging (elderly group) on Red blood cell distribution width (Anisocytosis), a comparative study between young and elderly subject

As this RDW parameter is available since the introduction of automated haematology analyzer; their clinical significance is under way. Increased RDW is found in hepatic, renal, cardiac, endocrinal and many metabolic abnormalities. It is found to be an independent marker of disease and in future we expect some prognostic value also. The most interesting observations are the association of RDW with erythropoietin deficiency and rather more with erythropoietin resistance. In this article we have studied the relation between RDW and aging and the mean value of RDW amongst young group with elderly group of people. Soon more researches will reveal whether the anisocytosis is cause or effect of disease and will able to reply whether the anisocytosis is independent disease or not. In this article we have try to study the effect of and correlate the age and RDW especially young and elderly group of people.

To study the Impact of aging on Red blood cell distribution width (RDW) and compare the RDW among young and elderly group

Data collected from camps organized by NSS Unit in AMCMET medical college in college and elderly houses in Ahmedabad

Subjects: 177 adults 94 young and 83 elderly.

Result and Outcome: Comparation of Means and Starndard Deviation of RDW of Young and Elderly Group of Subjects

Obsevation and Results: Mean Values of RDW of Young N1 Group and Elderly Group N2 WERE Compared and Found That Aged Group HAD Statistically Significantly More RDW Compared to Young Group.

The study documented the fact that the Red cell Distribution Width is increased statistically significantly amongst elderly group suggesting that there significant anisocytosis is prevailed among elderly aged group of persons. With introduction of computed automated hematology analyzer, RDW is relatively a new hematology parameter and current role of the parameter is under way. RDW is a useful for differential diagnosis of anemia especially Beta thalasemia trait and iron deficiency anemia. It is suggested that RDW is raised even before overt hematological parameter of anaemia and also useful for early detection of anaemia in pregnancy. Studies have shown that raised RDW i.e. anisocytosis is associated with decrease in serum erythropoietin or erythropoietin resistance. As wide a variety of human disorders are found to be associated with anisocytosis so increased RDW behaves as a biomarker itself and may be a potential target of future as independent disease process but more interventional studies are required. RDW is a simple and inexpensive parameter, which reflects hematological risk factors associated with liver, cardiac. lung, renal, endocrinal and metabolic abnormalities including cancer and genetic anomaly such as shortening of telomere length. In Future more researches will reveal RDW as a valuable for many clinical conditions as diagnostic, therapeutic and prognostic marker.