Chemistry Department, the Islamic University, Gaza P.O. Box 108 Gaza, Palestine.
A number of α, β-unsaturated carbonyl compounds were prepared by condensing of 2-formylfuran, 2-formylpyridine and 2-formylthiophene with acetone, acetophenone, 3-methyl-acetophenone, -chloroacetophenone and ethyl methyl ketone in ethanolic NaOH solutions. These compounds were tested for antibacterial activity against Escherichia coli.(E. coli). It was found that the mesomeric and the hyperconjugation effects have a strong influence on the antibacterial activity.
