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Two derivative spectrophotometric methods were developed for the analysis of binary and ternary mixtures containing clidinium bromide with other drugs.
The first method is based on the use of derivative compensation technique for the determination of this drug in two binary mixtures containing either chlordiazepoxide or trifluperazine. The second method was developed for the assay of clidinium bromide in a ternary mixture containing chlordiazepoxide and its degradation product. It is based on the use of the first derivative of the ratio spectra, and measurement at zero-crossing wavelengths. The ratio spectra were obtained by dividing the absorption spectrum of the mixture by that of chlordiazepoxide and the concentration of clidinium is determined from a respective calibration curve. The described methods were applied for the determination of these combinations in synthetic mixtures and dosage forms.
Derivative compensation method, Absorption spectrophotometry, Derivative ratio method, Zero-crossing, Binary and ternary mixtures, Clidinium, Chlordiazepoxide, Trifluperazine
