* Dept. of Biotechnology, D.R.W. College, Gudur. Email: kishandar@gmail.com.
1Dept. of Zoology, D.R.W. College, Gudur.
2Dept. of Zoology, S.V.University, Tirupathi.
The present investigation was aimed at determine the effect of imidacloprid on AChE enzyme system in different regions like Striatum, Hippocampus, Medulla, Cerebral cortex and cerebellum of brain of albino rat. The LD50 value was determined by using Finney et al. The LC50 value 400mg/1000gm body weight was found in the present investigation. The animals were exposed to sub lethal concentration of imidacloprid. After stipulated period AChE activity levels and ACh content were estimated by using standard methods. AChE Levels were significantly decreased in toxin exposed rats in all regions of the brain when compared to control rats. Contrast to AChE levels ACh levels was significantly elevated. The results found in the present study clearly indicated that imidacloprid blocks the cholinergic enzyme system.
Pesticide toxicity, Acetyl choline, Acetyl cholin esterase, Imidacloprid, Albino rat
