Oral Toxicity of Fenitrothion in Wistar Rats: A Biochemical and Histopathological Study

The present study was undertaken to evaluate subacute toxicity of orally administered fenitrothion (FNT) in rats based on the biochemical and histological examination. The study was conducted on 8-week old male Wistar rats that devided into four groups (three experimental groups and one control group), were treated orally with different doses (25, 50, 100 mg/kg) of fenitrothion for 28 consecutive day. After treatment, blood samples were collected for biochemical studies, also liver and kidney samples were taken for histological studies. Our results demonstrated that exposed groups led to significant dose-dependent increase in serum glucose and cholesterol levels. Serum total protein and triglycerides were decreased not significantly in exposed groups when compared with control. Our results showed that the histopathological changes in the liver were mainly represented by parenchymatous degeneration of hepatocytes with mild necrosis, leucocytic infiltration in the portal area, severe congestion and hemorrhage. Marked tubular dilation, hydropic degenerescence in tubular epithelium, moderate congestion and hemorrhage in the cortical and medulla part of the kidney were recorded. Generally the degrees of observed variations were found to be dose dependent.