The disposition of amikacin in urine was studied after a single intravenous administration @ 10 mg/kg body weight in six healthy goats. The mean concentration of amikacin in the urine samples ranged from 0.24 ± 0.06 to 1037.0 ± 126.7 μg/ml over a period of 30 hours. The peak urine concentration (1037.0 ± 126.7 μg/ml) was recorded at 20 min. The drug appeared in the urine in therapeutic concentration (2 μg/ml) at 2.5 min and the mean therapeutic concentration persisted for 12 hr. Amikacin may be used @ 10 mg/kg intravenously at 12 hr intervals for treating urinary tract infections caused by susceptible bacteria in goats.
