Pharmacokinetics and distribution of enrofloxacin in plasma, milk and urine were studied after a single intravenous dose of 5 mg/kg in six healthy goats. Therapeutic concentration of ≥0.12 μg/ml was maintained up to 10, 30 and > 48 hr in plasma, milk and urine, respectively. The drug showed a distribution half life (t½ α) of 0.60±0.10 hr and elimination half life (t½ β) of 2.82±0.33 hr. A value of 1.11±0.22 for tissue to plasma concentration ratio (T ≈ P) and large volume of distribution (Vdarea) of 2.34±0.54 L/kg indicated that the drug is distributed well in different body tissues and fluids. A total body clearance value (Cls) of 9.40±1.36 ml/kg/min was observed.
