Cypermethrin is a synthetic pyrethroid insecticide used to control pests in domestic, industrial and agricultural situations. This study was carried out to investigate the acute oral toxicity and histopathological changes of cypermethrin in albino rats. According to Finney's probit analysis method, at 48 h LD50 value of cypermethrin in rats was found to be 205 mg/kg bw by gavage. Behavioral changes in rats after oral administration of cypermethrin showed motor signs. On exposure to sublethal doses (41 mg/kg bw) of cypermethrin as single dose, double dose and multiple dose, mild to severe histological changes in duodenum, lungs and testis were observed by hematoxylin and eosin staining.
LD50, Behavioral, Histopathological studies, Cypermethrin, Rat
