*Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana- 141004, Punjab, India, E-mail: 6dkocher2002@yahoo.co.in
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House rats trapped from poultry farms of PAU, Ludhiana (Punjab) were orally administered with lethal dose (36mg/kg) of cholecalciferol (vitamin D3). Histopathological examination after single oral intake of cholecalciferol exhibited toxicity in heart in the form of calcification in the myocardium and in tunica media layer of the coronary blood vessels along with the muscular necrosis. Marked congestion of alveolar capillaries, hemorrhages in the air spaces, edema, emphysema were the observations made in the lungs of cholecalciferol fed rats. Mineralisation was evident both on mucosal and serosal sides of stomach. In kidneys, there was mineralisation in cortex and medulla. In liver, hepatic cells showed degeneration, dilation of hepatic sinusoids and marked centrilobular necrosis due to cholecalciferol toxicity.
Cholecalciferol, Histopathology, House rats, Hypercalcaemia, Toxicity, Vitamin D3
