1Department of Pathology, College of Veterinary and Animal Sciences, Mannuthy, Kerala-680 651, India
2Institute of Animal Health and Veterinary Biologicals, Bangalore-560024, India
Department of Veterinary Pathology, KVAFSU, Bangalore-560 024, India
*Corresponding author's e-mail: dhanushkb@gmail.com
Online published on 21 February, 2015.
The aim of the study was to compare the effects of Eugenia jambolana (EJ) extract and glibenclamide on streptozotocin (STZ) induced hepatotoxicity in rats. Wistar rats were divided into four groups: untreated control (UC), untreated diabetic (UD), EJ (200 mg/kg) treated diabetic (ED) and glibenclamide (0.6 mg/kg) treated diabetic (GD) orally for 45 days. There was various evidence of hepatotoxicity, including significant increase (P<0.001) in serum transaminases activity and histopathological findings in UD rats. In ED group, cellular injury was minimal and the hepatocytes maintained a better morphology when compared to UD rats. The substantially elevated serum transaminases were restored towards normal by the extracts. Findings indicate that EJ extract may have a preventive effect on STZ induced hepatotoxicity and also has potential hepatoprotective activity when compared to GD rats.
Eugenia jambolana, Hepatotoxicity, Liver, Serum transaminases, Streptozotocin
