1Department of Gynecology and Obstetrics, Faculty of Medicine, Gaziosmanpasa University, Tokat, 60030, Turkey
2Department of Gynecology and Obstetrics, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey
3Department of Gynecology and Obstetrics, Faculty of Medicine, Ataturk University, Erzurum, Turkey
4Department of Gynecology and Obstetrics, Sakarya Training and Research Hospital, Sakarya, Turkey
5Department of Pathology, Faculty of Medicine, Erzincan University, Erzincan, Turkey
6Department of Cardiology, Faculty of Medicine, Erzincan University, Erzincan, Turkey
7Department of Cardiology, Bayburt State Hospital. Bayburt, Turkey
8Department of Biology, Art and Science Faculty, Erzincan University, Erzincan, Turkey
9Department of Pharmacology, Faculty of Medicine, Erzincan University. Turkey
Department of Gynecology and Obstetrics, Faculty of Medicine, Gaziosmanpasa University, Tokat, 60030, Turkey
*Corresponding author's e-mail: durdualtuner@gmail.com
Online published on 5 November, 2018.
An ischaemia/reperfusion (I/R) injury in an organ can also cause damage to other organs. In this study, the effects of nizatidine were investigated on ovarian I/R injury and subsequent heart damage in rats. Rats were divided into groups; ovarian I/R (IRG), nizatidine 25 mg/kg+ ovarian I/R (NIR), and control (CG) groups. The NIR and IRG groups were given 2 hours of ischaemia followed by 2 hours of reperfusion by applying, and subsequently releasing, a vascular clip to the right ovarian artery. While oxidant levels in the IRG group were higher than NIR and CG groups, antioxidant levels were lower. Necrosis, congested blood vessels, haemorrhage, leukocyte infiltration and oedema were observed in the ovarian and heart tissues of the IRG group. These findings were reduced in the NIR group. Nizatidine suppressed oxidative stress in ovarian and heart tissues and may be useful in prevention of I/R-induced ovarian and cardiac injury.
Ischaemia, Nizatidine, Ovary, Reperfusion, Rat
