Key Laboratory of Exercise and Health Sciences of Ministry of Education at the Shanghai University of Sport, 188 Hengren Road, Shanghai, 200438, China
*Corresponding author's e-mail and address: h6yf@163.com Shanghai University of Sport, Shanghai, 200438, China
High-fat-diet (HFD) induced BPH mice model used to examine how aerobics exercise prevents the development of BPH and try to find the mechanism. Materials and Methods: C57BL/6J mice were randomized into three groups for a 6-week intervention: Control group (Co, n = 8) and Diet group (Di, n = 8) fed standard diet, and Exercise and diet group fed standard diet meanwhile run on a treadmill at 12m/min, 30 min/day, 6 days/week (Ex+Di, n = 8). Body weight (BW), fat, prostate weight (PW), prostate index (PI), Estradio(E2), Testosterona (T) and estrogen receptor(ER) were detected. Results: The Di had a higher BW, fat, PW and PI, compared to Co and Ex+Di. BW and PI in Ex+Di significantly lower compared to Di, thus running prevented increase in BW and PI. Although, E2 and T in Di and Ex+Di haven't seen anything statistically significant, compared with Co. However, ERα in Ex+Di (0.039±0.012 ng/ml) was significant reduced (P<0.05) compared with Di (0.046±0.011 ng/ml); Compared with Di (0.032±0.009 ng/ml), ERβ in Ex+Di (0.039±0.011 ng/ml) was significant reduced(P<0.05). Conclusion: Obesity is an importantriskfactor for the development of BPH. It may also provide scientific evidence to promote weight loss and aerobic exercise beneficial adjuvant therapies for BPH.
Aerobic exercise, Benign prostatic hyperplasia, ERα, ERβ, Obesity
