1Division of Medicine, Indian Veterinary Research Institute, Izatnagar, Bareilly-243 122, Uttar Pradesh, India
2Department of Veterinary Clinical Complex, Faculty of Veterinary and Animal Sciences, RGSC- Banaras Hindu University, Barkachha, Mirzapur-231 001, Uttar Pradesh, India
3Department of Veterinary Medicine, CVSc and AH, Central Agricultural University, Selesih, Aizawl-796 015, Mizoram, India
4Indian Veterinary Research Institute, Sanjaynagar, Bengaluru-560 024, Karnataka, India
5National Research Centre on Yak, West Kameng-790 101, Arunachal Pradesh, India
6Division of Surgery and Radiology, Indian Veterinary Research Institute, Izatnagar, Bareilly-243 122, Uttar Pradesh, India
7Central Institute for Research on Cattle, Meerut-250 001, Uttar Pradesh, India
*Corresponding Author: K. Mahendran, Division of Medicine, Indian Veterinary Research Institute, Izatnagar, Bareilly-243 122, Uttar Pradesh, India, Email: mahivet2002@yahoo.co.in
Online Published on 30 March, 2022.
Canine cardiovascular problems are commonly seen in veterinary medicine. Cardiac abnormalities in canine can be diagnosed by various means like electrochardiography, radiography, blood pressure measurement, echocardiography and biomarkers like troponins and peptides specific for heart.
The present study was conducted to evaluate different biomarkers such as cardiac troponin T (cTnT), atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) for the diagnosis of cardiac diseases in comparison to echocardiography in canine. A total of 40 cases were included in the study, out of which 26 cases found to be positive for cardiac affections as confirmed by echocardiographic examination.
The serum concentration of cTnT and BNP were found significantly (P<0.05) elevated in dogs having cardiac as well as cardiac along with renal affections. ANP values were significantly (P<0.05) increased in dogs having both cardiac and renal diseases as compared to dogs with cardiac diseases only. Biomarkers like cTnT, ANP and BNP were compared with echocardiography (gold standard). The BNP was having the highest sensitivity (88.46%) and specificity (78.57%) as compared to cTnT and ANP. From the study, it is concluded that BNP can be used as suitable biomarker than cTnT and ANP for the diagnosis of cardiac diseases in canine. It can be used as a biomarker for cardiac diseases under field conditions where facilities for echocardiography are not available.
Atrial natriuretic peptide, B-type natriuretic peptide, Canine, Echocardiography, Troponin T
