Efficacy of paromomycin sulphate for the treatment of cryptosporidiosis in goat kids

This study aimed to evaluate the therapeutic efficacy of paromomycin sulphate on serum amyloid A (SAA) and haptoglobin (Hp) in Cryptosporidiosis in goat kids.

In the study, stool samples were taken from the kids and Cryptosporidium was detected via the rapid test kit. Then, by examining the same stool samples microscopically, we included 9 kids in the study and 50 mg/kg of paromomycin sulphate was administered to the kids in which Cryptosporidium spp. was detected for five days as a treatment. For the SAA and Hp estimation, blood samples were drawn from the kids in the pre and post treatment stages.

In the kids with Cryptosporidium, the concentrations of SAA and Hp were measured as (SAA; 17.10±4.18 ng/mL Hp; 2.68±1.08 μg/mL) in pre-treatment and as (SAA; 9,71 ±4,13 ng/mL, Hp; 1,23±0,64 μg/mL) in the post-treatment stage (p<0,05). In accordance with these findings, we suggest that routine measurements of SAA and Hp concentrations of the goat kids with diarrhea due to cryptosporidiosis could be of value in follow up of treatment, determining the severity of the infection, selection of therapy and monitoring the efficacy of the preferred treatment protocol and in detection of subclinical infections.