1Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia
2Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia
*Corresponding Author: Jameel Al-Tamimi, Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia, Email: jhattamimi@gmail.com
Online published on 9 August, 2024.
To investigate the therapeutic effects of a combination of citric acid and Se-NPs against carbon tetrachloride (CCl4)-induced renal damage in rats.
Twenty-four rats were divided into three groups (n=8 each). Group 1 (control) received the vehicle, while Group 2 received a single dose of 1 ml/kg CCl4 in liquid paraffin (1:1 volume) via intraperitoneal injection. Group 3 was administered a single dose of 1 ml/kg CCl4 in liquid paraffin and then treated twice a week for three weeks with a dose of 2.5 mg/kg Se-NPs. One-way ANOVA and Tukey's method were used to compare the overall effects of each treatment.
CCL4 elevated MDA levels and decreased GSH levels in group 2 animals compared with those in the control group. Se-NPs significantly restored the oxidative stability in group 3. We found that CCL4 significantly increased its effect on renal function, whereas Se-NPs restored the renal structure affected by CCL4. As a result, Se-NPs can potentially reduce the markers of renal injury caused by CCl4, while also restoring oxidative stability and renal structure and function.
CCL4, Citric acid, Nephrotoxicity, Oxidative stress, Selenium nanoparticles
