Evaluating the Efficacy of Effect of Eucalyptus camaldulensis Leaf Extracts Grown in Sandy Habitats on Histological and Gene Expression Changes in the Liver of Mice Infected with Plasmodium chabaudi

The plants are considered to be living chemical factories responsible for the production of a wide variety of secondary metabolites (SMs). Geographical and ecological differences result in different chemical compositions even within the same plant. Medicinal plants are promising options at antiparasitic. this study aimed to examine the impact of Eucalyptus camaldulensis leaf extracts (ECES) from sandy environments on the histological changes and gene expression caused by Plasmodium chabaudi infection in the liver.

We analyzed E. camaldulensis leaf extracts from sandy habitats using GC mass spectrometry, leading to the anticipated identification of 33 compounds. we determined the suitable dose and We divided the mice into five groups before they were infected with P. chabaudi: Group 1 represents the non-infected control group without treatment; Group 2 is the uninfected treated group that received 100 mg/kg ECES; Group 3 consists of the infected group that received no treatment; Group 4 includes the infected treated group that received 100 mg/kg ECES; and group 5 includes the infected group treated with chloroquine.

study has demonstrated that the extract of E. camaldulensis leaves can mitigate the damage to liver tissue resulting from a P. chabaudi infection. Additionally, ECES successfully regulated the expression of liver cytokines, IL-1β, IL-6 and IFN-γ, in mRNA. When the parasite P. chabaudi causes liver injury.