1Department of Biology, College of Sciences, Taif University, Taif-P.O. Box 11099, Taif21944, Saudi Arabia
*Corresponding Author: Jawaher J. Albaqami, Department of Biology, College of Sciences, Taif University, Taif-P.O. Box 11099, Taif21944, Saudi Arabia, Email: jabaqami@tu.edu.sa
Online published on 21 January, 2026.
Ceftriaxone (CF) shows high and wide range of the potent antibacterial activity with rare some side effects, a long half-life. Now new transition metal drug complex attract more attention for evolving of new capacities with multi-therapeutic approach such as anticancer activities.
CF/Zinc (CF/Zn) complex was prepared and characterized via the transmission and scanning electron microscope. CF/Zn complex was prepared in (1:1) ceftriaxone: Zn+2 ratio.
(CF) coordinated as a tetradentate ligand towards zinc metal ion with the molecular formula [Zn(CF)(H2O)2].2H2O. The particle size and morphological surface for zinc complex was examined by using of many analyses: SEM, EDX, TEM, TGA/DTG and X-ray diffraction. This study investigated the effect of CF/Zn metal complex as a potent anticancer agent against three cancer cell lines (Breast adenocarcinoma MCF-7, Hepatocellular carcinoma HepG-2 and large cell lung cancer H460). The synthesized complex showed great anticancer capacities against the three cell lines at conc. 10 ug/ml and the living percentages were: 95.44, 90.6 and 94.04 μg/ml respectively and inhibited the proliferation of the cancer cells at conc.100 ug/ml and the living percentages were 90.35, 80.25 and 84.26 μg/ml. Exposure to CF/Zn complex even at very low concentrations elevated anticancer capacities of CF against three dangerous and common cancer types worldwide.
Antibiotics, Antioxidant activity, Bacterial resistance, Ceftriaxone
