1Department of Biology, College of Science in Zulfi, Majmaah, 11952, Saudi Arabia
2Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt
3Department of Zoology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia
4Department of Biology, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, 11564, Saudi Arabia
5Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, 11759, Egypt
6Department of Zoology, Faculty of Science, Kafrelsheikh University, Kafr Elsheikh, 33516, Egypt
*Corresponding Author: Shaimaa M. Kasem, Department of Zoology, Faculty of Science, Kafrelsheikh University, Kafr Elsheikh, 33516, Egypt, Email: shaimaakasem48@yahoo.com
Online Published on 07 July, 2025.
This study was intended to investigate the prospective role of Cassia alata extract as an anticoccidial, anti-inflammatory and hepatoprotective agent against Eimeria papillata parasitic infection. Therefore, this study was intended to investigate the potential role of Cassia alata extract as an anticoccidial, anti-inflammatory and hepatoprotective agent against Eimeria papillata parasitic infection.
For this investigation, a total of 25 male swiss albino mice were allocated into 5 equal groups. Group I: negative control (Cont), Group II: administrated with Cassia alata extract (CE) at a dosage of 500 mg/kg body weight, Group III: infected group with E. papillata (Inf), Group IV: infected-treated with Cassia alata extract (Inf-CE) at a dosage of 500 mg/kg body weight and Group V: infected-treated with amprolium at a dosage of 120 mg/kg body weight (Drug). Mice were infected orally with an approximate 1 × 103E. papillata sporulated oocysts excluding I and II groups. One-hour post infection, mice of groups IV and V were received the recommended doses of treatments orally once a day for 5 sequential days. Upon treatment for 5 days, all mice were sacrificed and growth performance, histopathological, histochemical and oxidative stress assessments were examined.
An enhancement in body weight (-2.33±0.58%) and feed intake (130.33±4.51 grams) in relation to the body weight (-4.67±0.58%) and feed intake (98.00±4.36 grams) of the Inf group was observed. Improvements in liver structure alterations induced by E. papillata was recorded with a noticeable increase in its carbohydrates (6.04±0.45%) and protein (12.46±1.13%) content. Moreover, considerable reduction in hepatic nitric oxide (59.13±4.59 Umol/g) and malonaldehyde (22.07±1.20 nmol/mg) and an elevation in glutathione (18.20±1.79 ng/mg) and glutathione peroxidase (111.53±8.95 ng/mg) were documented. In summary, CE treatment could significantly ameliorate liver injury, oxidative stress and inflammatory reactions caused by E. papillata parasitic infection.
Anticoccidial, Antioxidant, Cassia alata, Hepatoprotective, Histochemistry
