Indian Journal of Animal Research

SCOPUSWeb of Science
  • Year: 2025
  • Volume: 59
  • Issue: 3

Potential Impacts of Dried Green Coleus forskolin Leaves on Thermo-tolerance Parameters, Blood and Plasma Profiles in Anesthetized Mice

  • Author:
  • A.A. Mohammed1,*, M.S. El Sayed2, I. Al Gherair1, S. Al-Suwaiegh1
  • Total Page Count: 7
  • Page Number: 483 to 489

1Department of Animal and Fish Production, College of Agriculture and Food Sciences, King Faisal University, P.O. Box 402, Al-Ahsa, 31982, KSA

2Avian Research Center, King Faisal University, P.O. Box 402, Al-Ahsa, 31982, KSA

Abstract

Transient negative side effects of hypothermia, hyperglycemia and bradycardia due to general anesthesia using diazepam and xylazine drugs has been reported in mice.

Twenty albino male mice of 31.52±0.25 g body weight were classified into two groups; control group (G1) fed basal control diet versus C. forskolin group fed basal control diet containing C. forskolin leaves (G2; 1.5%) for four weeks. The mice were general anesthetized using xylazine and diazepam (XD) drugs (13.3 mg/kg BW diazepam and 26.6 mg/kg BW xylazine). Changes of rectal temperature (°C), glucose (mg/dl), pulse rate (pulse/min.) and partial pressure of oxygen (SPO2) were recorded at 0.0, 0.5 h, 1.0 h, 2.0 h, 3.0 h, 5.0 h and 7.0 h over general anesthesia. In addition, blood samples were collected and were subjected to blood and plasma analyses.

The results indicated that dietary C. forskolin caused significant decrease (P<0.05) in glucose values in addition to significant increase (P<0.05) in rectal temperature, pulse rate and SPO2 during the period hypothermia, hyperglycemia and bradycardia over general anesthesia. In addition, values of blood (RBCs, WBCs, PCV and Hb) and plasma parameters (TP, BUN, creatinine, AST and ALT, LDH) were normal due to C. forskolin supplementation compared to con trol diet. It could be concluded that 1.5% C. forskolin supplementation modulates thermo-tolerance responses, blood glucose indices, blood and plasma metabolites over general anesthesia.

Keywords

Anesthesia, Blood, Coleus forskolin, Hyperglycemia, Hypothermia