Clinical Evaluation Osteogenic Properties of Demineralised Bone Matrix (DBM) Xenograft in Femur Fracture in Dogs

Fracture is one of the common problems encountered in dogs. Fracture healing most of the times results into complications like delayed union, mal-union and non-union. To deal with these complications bone grafting is an important technique lying with clinicians.

The present study was conducted on 14 clinical cases of dogs with femur fracture. After preliminary examination the dogs were randomly divided into two groups. In group A (n=8) fractures were managed by intramedullary pinning and in group B (n=6), fractures were managed by IM pinning and demineralised bone matrix (DBM) xenograft implantation at the fracture site. The efficacy of the treatment was assessed on the basis of clinical, hemato-biochemical and radiographic observation on day 0 and on 7^th, 15^th, 30^th, 45^th and 60^th post-operative days.

The pain, lameness and weight bearing scores on the affected limb showed non-significant (P>0.05) variations between the two groups on different post-operative intervals. The hematological parameters also varied non-significantly (P>0.05) between the two groups. A significant (p<0.05) increase in the serum alkaline phosphatase values was observed upto 30^th post-operative day in group B animals as compared to group A animals and thereafter it gradually decreases and return to normal level on 60^th postoperative day in both the groups. Radiographic scores were better in group B dogs. Early radiographic signs of fracture healing were observed in group B dogs than group A dogs. No any graft related complications were observed during the study.