Indian Journal of Animal Research
SCOPUSWeb of Science
  • Year: 2026
  • Volume: 59
  • Issue: 8

Chemical and Spectroscopic Characterization of Novel Dexamethasone/Zn Complex as a Potent Antioxidant and Antibacterial Agent

  • Author:
  • Seham S. AlZahrani1, Samy M. El-Megharbel2*, Eman H. Al-Thubaiti1, Maha Ali Alghamdi1, Shahira A. Hassoubah3, Shaza Y.A. Qattan3, Bothaina A. Alaidaroos3, Najah M. Albqami3, Mohammad S. AL-Harbi4, Reham Z. Hamza4
  • Total Page Count: 12
  • Page Number: 1329 to 1340

1Department of Biotechnology, College of Sciences, Taif University, Taif-P.O. Box 11099, Taif21944, Saudi Arabia.

2Department of Chemistry, College of Sciences, Taif University, P.O. Box 11099, Taif21944, Saudi Arabia.

3Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, P.O. Box 80203, Jeddah21589, Saudi Arabia.

4Department of Biology, College of Sciences, Taif University, P.O. Box 11099, Taif21944, Saudi Arabia.

*Corresponding Author: Samy M. El-Megharbel, Department of Chemistry, College of Sciences, Taif University, P.O. Box 11099, Taif21944, Saudi Arabia. Email: samyelmegharbel@yahoo.com

Abstract

Dexamethasone (DX) is a glucocorticoid drug, its side effects, which include oxidative stress, despite being used to treat inflammatory diseases, Therefore, the primary goal of the study is to evaluate the new DX/Zn drug complex’s potent capacities with an increase in its antioxidant and antibacterial activities.

The DX/Zn novel complex was synthesized and characterized by means of magnetic susceptibility, SEM, TEM, elemental analysis and spectroscopic techniques (IR, 1HNMR, UV and X-ray diffraction). Antioxidant activities were performed via a lot of invitro antioxidant assays (ORAC, ABTS and Metal chelation), antibacterial actions against B. subtilis and E. coli.

DX is coordinated toward Zn ion as a monodentate ligand through the oxygen of (C=O).DX/Zn induced antioxidant activities via different antioxidant tests, it exhibits strong antibacterial properties against the bacterial strains B. subtilis and E. coli. Novel DX/ Zn novel complex is an effective antioxidant and antibacterial agent.

Keywords

Antibacterial activity, Antioxidant agent, Dexamethasone/Zn complex