Indian Journal of Animal Research
SCOPUSWeb of Science
  • Year: 2026
  • Volume: 60
  • Issue: 2

Clinico-Haemato-Biochemical Changes and Therapeutic Efficacy of Diminazene Aceturate and Artesunate against Bovine Babesiosis in Kashmir Valley

  • Author:
  • T. Ahmad2, N.A. Tufani1, A.U. Haq3, S.R. Tramboo4, I.M. Allaie4*, H.U. Malik1, N.A. Dar2, A.A. Dar1
  • Total Page Count: 7
  • Page Number: 307 to 313

1Division of Clinical Veterinary Medicine Ethics and Jurisprudence, Faculty of Veterinary Sciences and Animal Husbandry, Sher-e- Kashmir University of Agricultural Sciences and Technology of Kashmir, Srinagar-190 006, Jammu and Kashmir, India.

2Department of Animal Husbandry, Kashmir-190 001, Jammu and Kashmir, India.

3Department of Veterinary Medicine, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana-141 004, Punjab, India.

4Division of Veterinary Parasitology, Faculty of Veterinary Sciences and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shuhama Campus-190 006, Jammu and Kashmir, India.

*Corresponding Author: I.M. Allaie, Division of Veterinary Parasitology, Faculty of Veterinary Sciences and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shuhama Campus-190 006, Jammu and Kashmir, India. Email: dr.idreesallaie@gmail.com

Abstract

The purpose of the study trial was to assess therapeutic efficacy of diminazene aceturate and artesunate with respect to clinical, haematological and biochemical changes in the cattle affected by babesiosis.

For the analysis, a total of 16 clinically affected cattle were selected, with eight animals in each group. Eight healthy cattle were also selected under the control group. Clinical symptoms, blood smear microscopy and PCR-based molecular tools were used to confirm babesiosis. For the therapeutic trial, Groups I and II received treatment with diminazene aceturate and artesunate, respectively and the efficacy was estimated on the basis of survival rate, and improvement in the clinico-haemato- biochemical parameters.

The major clinical signs recorded were persistent high fever, pale mucous membranes, presence of ticks, decreased ruminal motility and haemoglobinuria. In diseased cattle (n=16) Hb, PCV and TEC levels were significantly (P<0.05) low but with a significant (P<0.05) increase in TLC as compared to the control group (n=8). Significantly (P<0.05) neutrophilia, lymphopenia, hypoglycaemia, hypoproteinemia, hypoalbuminaemia, was recorded in the diseased group. Moreover, significantly (P<0.05) increased levels of BUN, creatinine, AST, LDH and iron were recorded in the infected animals. Group I treated with diminazene aceturate was the most effective and cost- efficient treatment for bovine babesiosis compared to Group II treated with Artesunate.

Keywords

Artesunate, Babesia, Diminazene aceturate, Haemato-biochemical