1Department of Biology, College of Sciences, Taif University, Taif-P.O. Box 11099, Taif21944, Saudi Arabia.
*Corresponding Author: Jawaher J. Albaqami, Department of Biology, College of Sciences, Taif University, Taif-P.O. Box 11099, Taif21944, Saudi Arabia. Email: jabaqami@tu.edu.sa
Cefotaxime (CF), a semisynthetic cephalosporin, exhibits a broad antibacterial spectrum. The World Health Organization identifies antimicrobial resistance as a significant threat, necessitating the development of new antibiotics with diverse metal chelation mechanisms to mitigate side effects. Pancreatic cancer, a leading cause of cancer mortality, may be linked to magnesium (Mg), which could lower incidence risk due to its inverse relationship with type II diabetes mellitus, a pancreatic cancer risk factor. Recent studies on metallic complexes present promising therapeutic agents against various diseases.
Cefotaxime magnesium (CF/Mg) complex was characterized using C,H, N and S elemental analysis, conductivity value, IR, UV, XRD, SEM and TEM “Scanning and transmission electron microscope”, this paper explain the effect of CF and CF/Mg on oxidative stress by many antioxidant assays such as “ABTS, DPPH and metal chelation” assay and inhibition of viability of cancer cells (PANC-1).
The lower value of conductivity refers to that complex is non-electrolyte. The FT-IR for CF/Mg proved that antibiotic cefotaxime compound act as monoanionic tridentate ligand. In conclusion, CF/Mg complex exhibited high antioxidant activities. CF/Mg novel inhibited PANC-1 cellular viability. Thus, CF/Mg triggered promising results and acting as a potent agent with antioxidant capacities, with anticancer activity against the PANC-1 at suitable concentration.
Antioxidant, Cefotaxime, Magnesium, Metal complex, Pancreatic cancer cells
