1Department of Medical Biochemistry, Faculty of Medicine, Sanko University, Gaziantep, Turkey
2Department of Medical Biochemistry, Faculty of Medicine, Sutcu Imam University, Kahramanmaras, Turkey
*Corresponding Author: Meltem Gungor, Department of Medical Biochemistry, Faculty of Medicine, Sanko University, Gaziantep, Turkey, Email: meltemgngr@hotmail.com
Renal ischemia reperfusion injury (IRI) can be frequently observed in mandatory clinical situations such as organ transplantation, as well as in undesirable clinical scenarios such as embolic, thrombotic causes and hypotensive shock. This damage is an important pathological process that can occur in a wide clinical spectrum, such as acute renal failure and permanent renal failure. The effects of Quercetin and Resveratrol, substances with high antioxidant capacity that may have a positive effect on this pathological process, on renal IRI were examined by looking at Raftlin and 8-iso Prostaglandin F2alpha (8-iso-PGF2 a) levels.
Forty-two male Wistar-albino rats were divided into six groups (Control group; n=7, I/R group; n=7, Sham group; n=7, Quercetin group; n=7, Resveratrol group; n=7, Quercetin and resveratrol group; n=7). Quercetin (100 mg/kg) and resveratrol (100 mg/kg) was administered intragastricly in the treatment group. Only sham group was administered with 0.9% serum physiologic (NaCI). Raftlin and 8-iso-PGF2 avalues were measured by ELISA method. In the histopathological examination, the groups were evaluated in terms of hemorrhage, myocardial edema, myocytolysis and polymorphonuclear leukocyte infiltration.
It was observed that both quercetin and resveratrol molecules decreased Raftlin and 8-iso-PGF2a values. The group in which the two molecules were given together had the lowest values and it was determined that this value approached the control group value. Quercetin and resveratrol are thought to have a protective effect on renal IRI.
8-iso Prostaglandin F2alpha, Quercetin, Raftlin, Renal ischemia-reperfusion injury, Resveratrol
