1Department of Biology, College of Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia
2Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia
3Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia
4Department of Pharmacology and Toxicology, College of Pharmacy, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia
5Department of Biotechnology, College of Sciences, Taif University, Taif, P.O. Box 11099, Taif, 21944, Saudi Arabia
6Department of Chemistry, College of Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia
*Corresponding Author: Samy M. El-Megharbel, Department of Chemistry, College of Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia, Email: s.megherbel@tu.edu.sa
Nitazoxanide (NTZ) possesses a high potential activity against infections by various protozoa.
Nitazoxanide/zinc complex (NTZ/Zn) was synthesized and chemically characterized. Also, the antibacterial activity of NTZ/Zn was performed against Staphylococcus aureus strain. Then, twenty-one male mice were divided into three treatment groups as follows: Control, NTZ, NTZ/Zn complex; all animal treated for 30 successive days. The present study aimed to determine the physiological alterations, oxidative stress actions beside confirmatory part via the histopathological changes on the renal tissues of male mice and the possible ameliorative role of the recent complex (NTZ/Zn) to prevent the signs of renal toxicity.
Electrolytic nature of (NTZ/Zn) complex was confirmed. The bidentate characteristic of NTZ through the nitrogen atom of the amide group and oxygen atom of the ester group toward Zn (II) metal ion was confirmed using IR, UV for NTZ and its complex (NTZ/ Zn). SEM results showed that small particles agglomerated with different shapes. TEM showed that the zinc nitazoxanide complex has spherical black spots. Also, NTZ/Zn showed antibacterial activity against the S. aureus strain. The NTZ-treated group alone marked decline in renal antioxidant enzyme markers and elevated MDA). Meanwhile, The NTZ/Zn complex prevented the NTZ-induced renal injury as specified by ameliorating all the biochemical parameters with the appearance of glomerulus near o normal structure in NTZ/Zn complex. NTZ induced renal alterations that could be mitigated by NTZ/Zn complex via the physiological and biochemical mechanisms.
Antioxidant activities, Anti-parasitic drug, Nitazoxanide, Renal tissues
