1Department of Biological Sciences, College of Science, University of Jeddah, Jeddah, 21959, Saudi Arabia
10Department of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia
11Research Center of Basic Sciences, Engineering and High Altitude, Taif University, Taif, Saudi Arabia
2Department of Food Science and Human Nutrition, College of Agriculture and Food, Qassim University, 72, Buraydah, 51452, Saudi Arabia
3Department of Food Science and Nutrition, College of Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia
4Department of Food and Nutrition, Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah, Saudi Arabia
5Food, Nutrition and Lifestyle Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, 3270, Saudi Arabia
6Program of Food Sciences and Nutrition, Turabah University College, Taif University, P.O. 74 11099, Taif, 21944, Saudi Arabia
7Department of Clinical Nutrition, Taibah University, Universities Road, PO Box: 344, KSA, Medina, Saudi Arabia
8Department of Health Rehabilitation Sciences, University of Tabuk, Saudi Arabia
9Department of Clinical Nutrition, Faculty of Applied Medical Sciences, Umm Al-Qura University, P.O. Box 715, Makkah, 21955, Saudi Arabia
*Corresponding Author: Rokayya Sami, Department of Food Science and Nutrition, College of Sciences, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia, Email: rokayya.d@tu.edu.sa
The purpose of this study was to evaluate the effects of different edible oils on reproductive performances and liver functions in female albino wistar rats with hyperlipidemia by analyzing factors including pregnancy weight gain, estrous cycle length, fertility rate, pups number, offspring weight, liver weight, enzyme activities and oxidative stress.
The 56 rats were divided into seven different experimental groups (Control, olive, coconut, palm, soybean, sunflower and flaxseed), respectively.
All groups displayed comparable pregnancy weight gain, ranging from 11.25±0.49 g to 18.02±0.52 g. Meanwhile, the uterine weights of the soybean and palm oil groups were lower than those of the control, at 1.88±0.23 g and 1.87±0.26 g, respectively. While the palm and soybean groups had the lowest fertility rates of 64.11±4.41 % and 67.85 ±4.91%; the coconut, flaxseed and olive oil groups had the highest offspring weights of 6.77±0.47 g, 6.56±0.47 g and 6.43±0.47 g, respectively. Rats that received flaxseed oil produced the highest number of pups, 9.34±0.43 and the least amount of liver weight loss 5.44±0.44 g, suggesting possible advantages for the liver and reproductive system. Edible oils had varying effects on the activity of liver enzymes in obese rats. Oxidative damage was encouraged by coconut and palm oils. Olive and flaxseed oil groups had the highest increase of superoxide dismutases (SOD) and catalase (CAT) activities with the lowest malondealdehyde (MDA) levels. In hyperlipidemic female rats, flaxseed and olive oils generally enhanced the reproductive efficiency and liver function suggesting great protection against metabolic stress.
Antioxidant enzymes, Edible oils, Hyperlipidemia, Liver function, Oxidative stress, Rats, Reproductive performance
