Generation means analysis involving twelve generations of two crosses of wheat (Triticum aestivum L.) was used to elucidate the inheritance of tillers per plant, grains per spike, 1000-grain weight and grain yield per plant. The grain yield per plant and tillers per plant were mostly governed by the dominance, dominance x domimmce and dominance x dominance x dominance type of gene effects with larger magnitude but were unexploitable due to duplicate type of gene action. 1000-grain weight was found to be under control of both additive and non-additive gene effects with inadequate trigenic epistasis. Simultaneous utilization of both additve and non-additive genetic effects can be achieved by intermating of segregants in early segregating generation.