Tumor progression decreased life span of male mice as compare to female mice

The effect of gender differences in human development, aging, and disease is very common. There are measurable differences between men and women in cancer prevalence, mortality, and progression. The latest analysis of the National Cancer Institute Surveillance Epidemiology and End Results (SEER) database showed that the lifetime probability of developing cancer is 44.85% for males as compared to 38.08% for females. It was also noted that there are several cancers that are more frequent in male as compare to female and shows high mortality rate in male. Therefore, in the present study, the effects of gender variation on the development of Dalton's lymphoma (DL), a type of TransplantableT-cell lymphoma of spontaneous origin, mimic human T cell lymphoma were investigated.

Groups of normal and DL-bearing BALB/c mice of different days were taken to measure the IFN-γ, survival rate and different physiological changes in the body such as body weight and belly sizes of male and female mice. Cryosectioning of the reproductive organ of different days of male and female was also done to see the effect of the tumor progression.

It was found that the development of Dalton's lymphoma in mice was gender dependent and male mice were more prone towards DL progression. As a result, the male dies after 21 days, whereas female dies after 31 days of DL transplantation. The release of IFN-γ more in female as compare to male mice.

From the above findings, it can be concluded that development of cancer shows gender dimorphism. As a result, female mice shows less vigor of tumor progression as compare to male mice. Although the precise mechanism(s) underlying the observed gender dimorphism of the differential induction of tumor progression.