Defensive action of limonene on te induced BPH in male wistar rats

The Primary goal of the present investigation is to assess the defensive impact of Limonene on testosterone enanthate (TE) incited benign prostatic hyperplasia (BPH) in male Wistar rats. Wistar rats were segregated into six exploratory groups (n=6); Group 1 (Normal control), Group 2 (Disease control), Group 3 (Standard treated), Group 4 and 5 (Disease treated) and Group 6 (Normal treated) for imparting experimental treatment for a period of twenty one days. Testosterone Enanthate (TE) 25mg per day was used to induce benign prostatic hyperplasia in Wistar rats belonging to Groups from 2–5. At the end of the study Prostate gland was disengaged from all groups of lab animals after cervical dislocation for the biochemical estimation of MDA, Nitrite, Zinc, SOD and GSH and for the histopathological examination. Variation in the body weights were also recorded during the tenure of exploration.

TE induced BPH rat groups, after three weeks of treatment with Limonene has shown significant (p<0.05) downturn in the levels of prostatic weight, prostatic index, MDA, nitrite and zinc but expansion in the levels of SOD and GSH in a dosage reliant way, alike Finasteride drug, a therapeutic agent for the treatment of benign prostatic hyperplasia. At the end, 21 days of treatment has emphasized the defensive action of Limonene against TE induced BPH in Wistar rats in comparison to Finasteride, a commissary therapeutic agent that treats BPH.