Study on The Hypoglycemic Property of Sugar Apple (Anonasquamosa) Aqueous Leaf Extract on Alloxan Induced Wistar Rats (Rattusnorvegicus)

It is known that the incidence of diabetes mellitus is high all over the world, becoming the third “killer” of mankind after cancer and cardiovascular diseases, because of its high prevalence, morbidity and mortality.

This study was conducted to evaluate the anti diabetic activity of the aqueous leaf extract of Sugar apple via intra peritoneal route against hyper glycemic dose of Alloxan. Results of the study showed that there was a decrease in the blood sugar level of rats which was treated with the different concentrations of extract. However there was no significant difference among the different concentration after 7^thday.

Thus the present study indicates that the 100% aqueous leaf extract of Annonasquamosa has significant hypoglycemic activity in Alloxan induced diabetic rats due to the presence of more than one anti hyper glycemic principles.