1College of Science, Kufa University, Iraq
2College of Medicine, University of Babylon, Iraq
3College of Basic education, University of Babylon, Iraq
4University of Babylon-College of Science, Iraq
*Corresponding Author: E Mail: mona_diabetis@yahoo.com
Online published on 28 February, 2017.
Anti-depression drugs become modern commonly used in last decades used as anxiolytic and anticonvulsant dieses, the present study aimed to evaluation cytotoxic and genotoxic accumulation effect of alprazolam in white albino rats using cytogenetic assays like chromosome malformation, cells proliferation, plastindex and micronuclei formation in bone marrow cells of rats. The results show that drugs cause increased in aberration of chromosomes, plast cells and micronuclei formation. Also causes decreased in cell proliferation compare with negative andpositivecontrols.
Alprazolam, Chromosome Malformations, Cells Proliferations, Plastindex, Micronuclei Formation
