Effect of Solanum lmlycopersicum fruit extract on cancerous cecells OF Albino wistar rats

This study evaluated the prepreventive and ameliorative measures for ca ancer using simple dietary material (tomato). For this 26 d study, healthy control animals repr resented first group, receiving only standard feed d ve and deionized water. Group two were given lead nitrate at 100mg/kg BW concurrently wiwith tomato extract at 300mg/kg BW. Grou Group three were given only lead nitrate and normal feed and water. Representatives from 2 and d 3 were sacrificed and analysed at the end of 7d. 7d. Remaining group 3 animals were divided, some treated with 300mgkg⁻¹ BW tomato extraracct, some with 20mgkg⁻¹ BW of a known a anticancer drug and some were untreated for 7d.7d. Obtained results showed that ingestion of poison caused significant damage on the org gans -liver and kidney and resulted in a signnificant increase in body mean weight change of of 80g (female) and 20g (Male). Increased oorgans weight was thought to be due to the necrosi osis and apoptosis which could be attributed t to the accumulation of the lipids in the two organs. ns. Results also showed that female organs we were affected more than those of the male. Treat tment with extract significantly reduced the damage caused by the protoplasmic poison lead. The study concludes that supplementation on with tomato paste gave protection against leadd poisoning. Comparing the results of thhe preventive and ameliorative studies, the effec ct of the poison was best remedied when indivi viduals fed daily on tomato paste or sauce rather thahan post – effect treatment. Post prandial useuse of tomato paste or sauce can reduce strong cell de deteriorations (preventive).