Immunological Characterization of Immunoglobulin G towards House Dust Allergens

Immunoglobulins are γ-globulin proteins secreted by B cells that are found in blood or other bodily fluids of vertebrates which have the basic structural units each with two large heavy chains and two small light chains. Five different immunoglobulin isotopes are known in mammals, which perform different roles, and help to direct the appropriate immune response. Dust mites and pollen which are common in house hold dust and industrial dust has the main role in asthmatic allergy. Majority of severe allergic reactions are thought to be immunological and mediated via IgE but high serum concentrations of some IgG subtypes have been measured which are associated with in vitro degranulation of basophils and mast cells, the activation of the complement cascade. The premise behind this testing is that high circulating levels of IgG antibodies are correlated with allergy due to house hold allergens.