a spandana.vemullapalli, spandana valluri, Department of Biotechnology, KL University.
bDept of Botany & Microbiology, Acharya Nagarjuna University.
As high telomerase activity is observed in most cancerous cells, Telomerase represents a promising cancer therapeutic target. we investigated inhibitory effect of reverstrol on telomerase reverse transcriptase gene(h TERT) which is essential for telomerase activity. To assess the transcriptional effect, DLD-1 cells were cultured in presence of various concentrations of resveratrol and gene expression was subsequently measured culturing cells with reservatol resulted in down regulation of hTERT and c-myc expression. These results indicate that resveratol modulate the telomerase gene expression at transcriptional level. Cancer cells-telomerase-inhibition-hTERT, C-MYC gene-resveratrol.
